Phenytoin-induced gingival overgrowth in epileptic children

a clinical, histological and biochemical study
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Department of Pedodontics, School of Dentistry, Karolinska Institutet , Stockholm
StatementGoran Dahllöf.
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Open LibraryOL18072925M

[32] Modeer T, Dahllof G. Development of phenytoin-induced gingival overgrowth in non-institutionalized epileptic children subjected to different plaque control programs. Acta Odontol Scand. ; –Cited by: 2. Incidence of phenytoin induced gingival overgrowth in epileptic children: a six month evaluation Article (PDF Available) in Journal of Indian Society of Pedodontics and Preventive Dentistry 20(2.

Conclusions Epileptic children are highly burdened with gingival problems and liable to develop dental caries especially in primary dentition.

Phenytoin-induced gingival overgrowth is a well. The double-blind randomized study is the first to suggest that this vitamin worked to decrease the incidence of phenytoin-induced gingival overgrowth (PIGO) in children taking the anti-epileptic drug (AED).

The study was conducted at the All India Institute of Medical Sciences in New Delhi, India. 3. Discussion. Anticonvulsants are considered as potential etiologic agents of drug-induced gingival overgrowth 8 although the prevalence of Phenytoin-induced gingival hyperplasia vary from 13 to 50%, in community based studies on institutionalized patients.

9 The pathogenesis of gingival overgrowth is uncertain and not all patients taking anticonvulsants develop overgrowth. 10 Author: Antush Mittal, Shoyab Khan. F orty‐six mentally retarded epileptic patients being treated with phenytoin and phenobarbital were studied to determine the root/crown length ratios.

Forty‐five mentally retarded patients not receiving anticonvulsant drugs provided the controls. Further, because serum phenytoin levels have been related to severity of gingival hyperplasia, efforts were made to determine if the hyperplasia.

Gingival enlargement or overgrowth (GO) is a common complication of the anticonvulsant drug phenytoin (PHT). GO is evident in almost half of the patients receiving PHT therapy. PHT-induced gingival overgrowth (PGO) is more common in children than in. Thomas Modéer and Goran Dahllöf, Development of phenytoin-induced gingival overgrowth in non-institutionalized epileptic children subjected to different plaque control programs, Acta Odontologica Scandinavica, 45, 2, (81), ().

Crossref. Shlomo Barak, Isaac S. Phenytoin-induced Gingival Overgrowth. Phenytoin (hydantoin) prevents or reduces the incidence or severity of seizures associated with most types of epilepsy (grand mal), with the exception of petit mal.

Phenytoin is also often prescribed following neurosurgical operations or cranial trauma. Modeer et al, in a study of non-institutionalized epileptic children reported a significant correlation between Phenytoin induced gingival overgrowth and 3 variables – gingivitis, visible plaque index and duration of Phenytoin therapy.

Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, with varying degrees of inflammation.

One of the main drugs associated with GO is the antiepileptic. Thomas Modéer, Goran Dahllöf, Development of phenytoin-induced gingival overgrowth in non-institutionalized epileptic children subjected to different plaque control programs, Acta Odontologica Scandinavica, /, 45, 2, (), ().

Incidence of phenytoin induced gingival overgrowth in epileptic children: a six month evaluation. Prasad VN, Chawla HS, Goyal A, Gauba K, Singhi P. J Indian Soc Pedod Prev Dent, 20(2), 01 Jun Cited by 6 articles | PMID: Gingival enlargement or gingival overgrowth is the increase in the size of gingiva.

It is a common clinical condition usually seen in acute and chronic gingival inflammation. The enlargement of the gingival tissue may also occur due to many other reasons, which include drug intake associated, conditioned, neoplastic or false enlargements.

Lin K, Guilhoto L, TargasYacubian E. Drug - induced Gingival Enlargement. Part II. Antiepileptic drugs: Not only phenytoin is involved. J Epilepsy Clin Neurophysiol. ; 4.

Prasad VN, Chawla HS, Goyal A, et al. Incidence of phenytoin induced gingival overgrowth in epileptic children: a six month evaluation.

Thirty children aged years with epileptic disorders and receiving mono-drug therapy with Phenytoin, were selected from the Departments of Pediatrics and Neurology of PGIMER, Chandigarh to evaluate the development of gingival overgrowth induced by phenytoin over a period of six months.

• Introduced by Merritt and Putnam in • Drugs used for the treatment of epilepsy. • Phenytoin, ethotoin, mephenytoin, succinimides etc. • 50% of the patients • younger patients more prone. • appears in saliva • systemic administration accelerates the healing of gingival wounds in non- epileptic.

1 Ball DE, McLaughlin WS, Seymour RA, Ramali F. Plasma and saliva concentrations of phenytoin and 5-(4-hydroxyphenyl) phenylhydantoin in relation to the incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients.

J Periodontol 67 ; Effect of folic acid on recurrence of phenytoin-induced gingival overgrowth following gingivectomy. J Clin Periodontol ; Arya R, Gulati S, Kabra M, et al. Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children.

Description Phenytoin-induced gingival overgrowth in epileptic children EPUB

Neurol ; Gingival overgrowth incidence varies and is dependent on each patient and their drug regimen. Calcium-channel blockers may exacerbate the problem. Children tend to be more susceptible to gingival overgrowth than adults.

Tacrolimus: less gingival overgrowth but associated with oral ulceration and numbness or tingling, especially around the mouth.

Drug-induced Gingival (gum) Overgrowth occurs as a side effect of some systemic medications. Many terms have been used to describe gingival overgrowth (GO).The expression gingival hyperplasia (“ abnormal increase in the number of normal cells in a The drugs mainly associated with GO are: • Phenytoin, a drug used for the management of epilepsy, and other anti-convulsants such as sodium.

You have a 32 year old patient with epilepsy who presents with advanced phenytoin-induced gingival overgrowth between the maxillary and mandibular anterior teeth. He came in two months ago for scaling and root planning, but the enlargement did not improve. He uses a powered toothbrush twice a day and flosses once a day.

patients with phenytoin-induced gingival overgrowth. J Clin Periodontol ;25(1) Kimball OP: The treatment of epilepsy with sodium diphenyl hydantoinate. J Am Med Assoc ; Arya R, Gulati S, Kabra M, Sahu JK, Kalra V.

Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children. The results obtained could not be compared with the observations of other studies as the indices followed were either different; modified Harris and Ewalt index in a study by Prasad et al. on the role of folic acid in the prevention of phenytoin-induced gingival enlargement on 60 epileptic children in the age range of years; or even using.

Fathima Fazrina Farook, Mohamed Nuzaim M. Nizam, Abdulsalam Alshammari, An Update on the Mechanisms of Phenytoin Induced Gingival Overgrowth, The Open Dentistry Journal, /, 13, 1, (), ().

This study was conducted to determine the occurrence, severity, and risk factors of gingival enlargement in children treated with valproate and other nonvalproate antiepileptic drugs.

A cross-sectional study was carried out in which data obtained from 68 epileptic children under treatment were compared with those from 50 controls.

2 Marakoglu I, Gursoy UK, Cakmak H, Marakoglu K. Phenytoin-induced gingival overgrowth in un-cooperated epilepsy patients. Yonsei Med J ; 45 (02) ; 3 Brown RS, Arany PR.

Details Phenytoin-induced gingival overgrowth in epileptic children PDF

Mechanism of drug-induced gingival overgrowth revisited: a unifying hypothesis. Oral Dis ; 21 (01) ee61 ; 4 Pette GA, Siegel MA, Parker WB.

abnormal overgrowth of gingival tissues. As the records revealed of a single episode of epileptic attack 1 ½ years back for which she was on sodium valproate since then.

Her parents had case of Phenytoin induced GE. Other anticonvulsants associated with overgrowth are carbamazepine, primidone, phenobarbital.

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Overgrowth of the gums (gingival hyperplasia) is more common in children than in adults. It can be reduced by vigorous brushing, daily flossing, and regular visits to the dentist, who may recommend additional treatments. Prasad VN, Chawla HS, Goyal A, Gauba K, Singhi P.

Incidence of phenytoin induced gingival overgrowth in epileptic children: a six month evaluation. J. Gingival enlargement or overgrowth is a common disease of gingiva. The causative factors may range from inflammation due to local factors to conditioned enlargement and neoplastic enlargements.

They commonly present as bulbous interdental gingival, diffuse swelling of gingival. Due to the unaesthetic appearance of the overgrown gingiva, treatment becomes inevitable.Phenytoin-induced gingival overgrowth Individuals with inflamed gums and plaques are predisposed to gingival overgrowth when phenytoin is used.

The articles were mainly discussing the side effects of phenytoin (dilantin) as a treatment option for seizures in epileptic children who were institutionalized.Background:The mechanism concerning gingival overgrowth as a side effect of phenytoin, a therapeutic drug for epilepsy has been still unclear.

As one of mechanisms, by measuring the intracellular calcium concentration ([Ca2+]i) of the gingival fibroblasts, it has been advocated that there is relationship between gingival overgrowth and phenytoin-induced alterations in the [Ca2+]i in gingival.